Stem cells grown from human skin used to study fatty liver disease

Fatty liver disease affects hundreds of millions of people worldwide, but studying animals in the lab does not allow us to fully understand this uniquely human disease. Could using stem cells grown from human skin lead to better treatments? A team of innovative researchers at Vrije Universiteit in Brussels – led by Dr. Robim Rodriguez and Professor Tamara Vanhaecke – aims to find out.


Move over monkeys: Understanding viral infections without using animals

Mosquito-borne viruses such as Zika and dengue are often studied using monkeys, mice and other animals, even though vaccines shown to protect monkeys from infection often don’t work in people. But is using animals really the most effective way to unlock the secrets to successfully preventing, treating—and even curing—these viral diseases? Find out what Dr. David Pamies at the University of Lausanne (formerly of the Johns Hopkins Center for Alternatives to Animal Testing)—along with his colleagues at Johns Hopkins University and the National Institute of Allergy and Infectious Diseases’ Vaccines Research Center in the U.S.—are doing to upend the status quo. Learn more »


Early-career scientists awarded HTPC travel grants to attend JRC summer school on non-animal approaches

We are thrilled to announce financial support enabling three promising early career researchers to attend the European Commission’s Joint Research Centre (JRC) Summer School May 21-24 in Ispra, Italy, a week-long learning opportunity dedicated to non-animal approaches. These researchers have already shown impressive levels of dedication to the replacement of animals in their scientific careers so far and we are delighted to help further their education and training in innovative new technologies that do not rely on animals.

The summer school is a popular annual event for post-graduate researchers and early career researchers active in the fields of biomedical science and toxicology who are interested in learning about the latest advances in non-animal methods and technologies from experts in the field. Activities include debates, interactive sessions, poster presentations, and a visit to the EURL-ECVAM laboratories. The travel awards will help cover flight and accommodation costs for the researchers.

Nathalia Indolfo
São Paulo, Brazil

Nathalia actively developed and implemented non-animal approaches in her post at the Brazilian Biosciences National Laboratory (LNBio), where she was part of a project implementing OECD guidelines for the assessment of eye irritation and eye corrosion potential of chemicals using alternative methods.

Nathalia currently works at Natura, a Brazilian cosmetic company, where she is applying her knowledge and experience in non-animal methods as a product safety analyst.

Guilio Bracialente
Turin, Italy

Guilio is a chemical risk assessor and environmental consultant with extensive experience in assessing the potential risks posed by chemicals to human and environmental health. He has a particular interest in the risks and implications for health and the environment associated with products containing nanomaterials.

Giulio hopes that the summer school will provide him with a better understanding of in vitro and in silico non-animal methods that will be indispensable for his work in the regulatory arena.

Rohit Bhatia
Delhi, India

Rohit is an independent consultant focused on promoting the use of non-animal methods in research and testing. His background lies in chemistry and he has a proven track record of promoting the adoption of non-animal testing methods.

Rohit anticipates that attendance at the summer school will provide an exceptional opportunity to enhance his knowledge and learn from the best practitioners and experts in this area. He hopes that the knowledge and experience gained from the summer school will help achieve his objective of creating awareness and promoting the use of non-animal testing methods.


SOT breakfast meeting on global collaboration for non-animal safety assessment

Please join Humane Society International at the Society of Toxicology’s annual meeting for a breakfast session focused on global collaboration for non-animal safety assessment. Breakfast is included.

Tuesday, March 12
6:30 AM–8:00 AM
Hilton Baltimore
Room: Peale A-C
401 West Pratt St, Baltimore, MD


There has been significant progress globally over recent years in advancing the science to underpin non-animal cosmetic safety assessment.  This has facilitated legislative change within some countries; however, to achieve a global ban on the use of animals in cosmetic safety assessment there is still more to do. Today we are announcing the launch of a collaboration between Humane Society International (HSI), industry partners, and other interested groups to help shape future cosmetics legislation and share the decision-making approaches which are being applied to assess safety without animals. The associated investment in education and training will ensure that there is the ongoing ability to meet regulations which require non-animal safety approaches.

In this interactive session, we will share the overall objectives of this collaboration and highlight opportunities to join, present examples of non-animal safety approaches, and discuss priorities for education and training. Join us find out more and/or share your thoughts.


6:30     Welcome & introduction – Catherine Willett, Humane Society International

6:50     ICCR framework & NGRA case study- Paul Carmichael and Gavin Maxwell, Unilever

7:10     Cheminformatics and toxicogenomics to support toxicity assessment – George Daston, Procter & Gamble

7:30     Round Table – Priorities for education & training*

7:50     Audience input – Voting on Education & Training (mentimeter)

*Round table participants:

  • Rebecca Clewell, Principal Consultant, 21st Century Tox Consulting, LLC
  • Chris Barber, CEO, Lhasa
  • Jay Ansell, PCPC Vice President Cosmetics Programs
  • Warren Casey, Director of the U.S. National Toxicology Program’s Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), National Institutes of Environmental Health Sciences (NIEHS)

Learn more about the collaboration » 



We’re excited to tell you about a brand-new initiative that we are involved in: the Biomedical Research for the 21st Century (BioMed21) Collaboration.

BioMed21 brings together scientists and institutions from across Europe, Asia and the Americas who share a vision of a human-focused paradigm in health research. This unique mix of biomedical stakeholders provides both a broad, global outlook as well as deep ties at regional and national levels.

The new BioMed21 website was designed to be a hub for information related to innovative, human-specific approaches in health research, including relevant publications, funding opportunities, workshops, training opportunities, and other events.

The newsletter delivers top highlights to your inbox every quarter.

Follow BioMed21 Twitter for more frequent updates.

On behalf of the Human Toxicology Project Consortium team, we look forward welcoming you to the BioMed21 online community!


ICCVAM’s Strategic Roadmap now available in five languages

A Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products, which was published by the U.S. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) earlier this year, is now available in Chinese, Japanese, Korean, and Portuguese.

The roadmap incorporates the views of 16 federal regulatory and research agencies, several interagency workgroups, and public opinion, and is intended as “a resource to guide U.S. federal agencies and stakeholders seeking to adopt new approaches to safety and risk assessment of chemicals and medical products that improve human relevance and replace or reduce the use of animals.”

Access the official translations of the roadmap via the following links:


OECD announces new & updated guidelines for chemical safety tests

The Organization for Economic Co-operation and Development (OECD) recently adopted a set of new & updated guidelines for chemical safety testing—including endocrine-related endpoints, improved in silico predictions, and ‘me-too’ methods—that will reduce reliance on animal testing.

Accepted internationally as standard methods for safety testing, OECD guidelines are used by professionals in industry, academia and government involved in the testing and assessment of chemicals, including industrial chemicals, pesticides, and personal care products.

Learn more:


HSI & H&M sponsor New Approach Methods workshop in Shanghai

Humane Society International (HSI) and global fashion brand H&M teamed up to sponsor a recent workshop on new approach methods (NAMs) in Shanghai, China. Held June 11-13, the 8th Workshop on Alternative Methods provided more than 200 scientists from industry, government bodies, and academia with in-depth theoretical knowledge and hands-on experience in contemporary NAMs applicable to the safety assessment of cosmetics.

The conference attracted global attention from industry and academia interested in the practical application of NAMs. Sessions covered risk assessment for eye irritation and skin sensitization of cosmetics and concluded with a demonstration of OECD test guideline methods for skin irritation.

Dr. Andrew Rowan, chief scientific officer at The Humane Society of the United States, kicked off the meeting with a keynote lecture describing a vision of a new paradigm for medical research based on expansion of  human-relevant approaches. Dr. Rowan was later interviewed by shangzhibo tv and expressed enthusiasm for China’s potential role in the further development and promotion of the new approach methodologies, concluding that China could become a “world beater” in alternative methods.


OECD Calls for assays for Non-Genotoxic Carcinogens

The Organization for Economic Cooperation and Development (OECD) is looking for assays that could be used within the context of an Integrated Approach to Testing and Assessment to assess a chemicals potential for non-genotoxic carcinogenicity assessment. If you have or are developing such an assay, please let OECD know about it before June 15, 2018.

Please see the explanatory note and Excel assay collection template for reporting information about the assays to OECD.

Send all information to by Friday 15 June 2018.